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Exercising during pregnancy can benefit grandchildren: Study
Rajeev Choudhury
Exercising during pregnancy can have benefits spanning generations, researchers from Harvard’s Joslin Diabetes Center say.
In a research published in the journal, Molecular Metabolism, the researchers from the Center demonstrated that grand-maternal exercise during pregnancy improved the glucose tolerance in adult male and female grand offspring as they age, even if the offspring and grand-offspring do not exercise.
“While there has been growing evidence in recent years that maternal exercise has important effects to improve the metabolic health of first-generation offspring, remarkably, our current data demonstrate that maternal exercise has similarly robust effects to improve the metabolic health of second-generation adult male and female offspring,” the researchers wrote in their paper.
Interestingly, though the effect of the grand-maternal exercise could not be seen among young (16 or 24-weeks of age) second-generation male offspring’s body weights, at 36 and 50-weeks there was a main effect of grandmaternal exercise to decrease second-generation male offspring body weight.
Second generation males and females from exercise-trained mice had a lower proportion of fat mass and a higher proportion of lean mass at 51-weeks, the researchers further noted in their paper.
Performing glucose tolerance test in the second-generation offspring, the researchers found that the glucose tolerance among the second generation males of sedentary mice worsened with age, while the glucose tolerance among the second generation of exercising mice showed marked improvement from 24 through 50 weeks of age.
Similar results were observed among the female offspring, with second-generation female offspring from exercise-trained grandmothers maintaining their glucose tolerance as they aged, whereas those from sedentary grandmothers had a worsening glucose tolerance, researchers further noted.
“In addition to the striking effects of grandmaternal exercise on the second generation, our study demonstrates that male and female offspring are metabolically distinct during the first year of life,” the first author of the study, Ana Alves-Wagner, PhD, a senior post-doctoral fellow in the Goodyear laboratory says.
“This metabolically healthier phenotype of the F2 female mice was probably the reason that the beneficial effects of the grandmaternal exercise were generally less pronounced compared to male F2,” she adds.
“These findings suggest that maternal exercise could be an important tool to combat the detrimental cycle of metabolic dysfunction caused by obesity and type-2 diabetes in women of childbearing age,” the researchers concluded.
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