A Newspaper for the health conscious

Transfusion of stored blood can cause blood flow dysfunction

1 1 1 1 1 1 1 1 1 1 Rating 5.00 (1 Vote)

 DTMT Network
Researchers at University of Alabama (Birmingham) have shown that transfusion of stored blood could have adverse effects on patients, even leading to massive blood loss. Patients undergoing repeated blood transfusions with stored blood can have dysfunction in blood flow, increased injury and inflammation in critical organs and lung infection.

Transfusion of old blood is usually followed by bacterial pneumonia due to free heme group in degraded red blood cells (RBCs). The heme group bound to hemoglobin carries oxygen to the lungs as well as gives red colour to the blood.

However, free heme group induces inflammatory injury to major organs in diseases like sickle cell or sepsis as it activates toll-like-receptor 4 and releases inflammation mediator HMGB1. When blood is stored and transfused, the RBCs in the blood lyse open and release free heme.

The study was published in the journal PLOS Medicine, and involved resuscitated mice suffering trauma and hemorrhage after transfusion of either fresh or two-week old stored blood.

Resuscitation with stored blood increased bacterial lung injury, higher mortality, increased fluid accumulation and bacterial numbers in the lungs.

Leave your comments



  • No comments found


  • No comments found
GLS Pharma


Cubit Pharma

Medical Devices ASEAN 2018