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Abbott to study if OCT-guided stents improve clinical outcomes

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NEW DELHI: The study among 3650 patients will tell us if OCT-guided stents are better than traditional angiography.

Abbott has announced the launch of a new trial exploring long-term outcomes in patients who underwent stent implantation guided by optical coherence tomography as compared to angiography.

The trial is the first large-scale randomized global study using Abbott's OCT imaging in patients with high-risk, complex coronary artery disease. Patients in the study will be randomized to either OCT-guided or traditional angiography to guide placement of one or more Xience everolimus-eluting coronary stents, the company said in a statement.

During stent implantation guided by one of Abbott's OCT platforms, physicians use high-resolution images taken directly inside the patient's vessels to accurately measure dimension and choose a stent that best fits the vessel. OCT is also used to help physicians ensure the stent is fully expanded and is flush against a vessel wall, which are both important factors in reducing stent failure, it said.

The trials have enrolled up to 3,650 patients with high-risk, complex disease at 125 centers in North America, Europe and Asia to determine if OCT-guided stent procedures result in larger vessel diameters -- thus, allowing increased blood flow -- and whether this will improve clinical outcomes for patients compared to stent procedures guided by angiography.

Patients with complex disease may have multiple, or totally blocked arteries, or other diseases such as diabetes; and these patients account for an increasing number of cases.

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