21April2018

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Rise in lung cancer among non-smokers: Study

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 BS RAWAT
NEW DELHI: Environmental pollutants such as asbestos, arsenic, chromates or even breathing disorders such as tuberculosis and fibrosis have been correlated with adenocarcinoma prevalence.

A recent study by CORE Diagnostics has indicated a significant rise in lung cancer among non-smokers in recent years. The cancer, called adenocarcinoma, expresses first in the outer parts of the lungs.

Environmental pollutants such as asbestos, arsenic, chromates or even breathing disorders such as tuberculosis and fibrosis have been correlated with adenocarcinoma prevalence, the study said.

The study stated that genetic abnormalities related to the spread and regeneration of Non-Small Cell Lung Cancers (NSCLC) cells can now be targeted by specific molecules called Tyrosine Kinase Inhibitors (TKIs). These TKIs act as suppressors to the cancer related genes and successfully cause the tumor to regress.

Dr. Shivani Sharma, Pathologist, CORE Diagnostics, said, “The frequency of ALK mutations we found in our study correlates with the known frequency of ALK mutations in the Asian population. Hence, it is of utmost importance to test all non-small cell lung cancers for genetic mutations.”

Dr Sharma stated, “The clinical parameters from the study are comprised of data from 512 patients of which only 42 displayed ALK mutations between the age group of 24 years and 81 years, the mean being 57 years.”

The study recognizes an important trend in the treatment of lung adenocarcinoma via genotyping of the tissue from the tumor. It is recognized that mutations in EGFR, KRAS and ALK are mutually exclusive among adenocarcinoma subjects and the identification of a biomarker helps direct targeted therapy accordingly.

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