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Fosaprepitant

Fosaprepitant

It is prodrug of aprepitant, which is antagonist of human substance P/neurokinin 1 (NK1) receptors.

Indications

antiemetic with anticancer therapy.


Dosage

IV; 150 mg intravenously over 20 to 30 minutes approximately 30 minutes prior to chemotherapy.


Contra-Indications

patient taking pimozide, hypersensitivity.


Special Precautions

Paediatric: safety and efficacy not yet established. Pregnancy: Category B. Lactation: Data not sufficient. Elderly:Use with caaution.


Side Effects

fatigue, diarrhea, neutropenia, asthenia, anemia, peripheral neuropathy, leucopenia, dyspepsia, urinary tract infection, pain in extremity.


Ad 5