DIMERCAPROL

It binds to metals which produce toxicity by interacting with sulfhydryl containing enyzymes in the body. The dimercaprol-metal complex spontaneously dissociates at a slow rate; also dimercaprol is partly oxidised in the body; further emphasizing the necessity to have excess dimercaprol available in the body. But large amounts should not be given at a time.

Indications

Poisoning due to arsenic, mercury, gold, bismuth, nickel, thalium, antimony. As an adjuvant to cal. disod. edetate in lead poisoning. As an adjuvant to penicillamine in Cu poisoning and in Wilson’s disease.

Dosage

Usually 100 mg every 4 hrs, for 48 hrs, then 100 mg 8 hrly for 8-10 days. Wilson’s disease: 300 mg daily for 10 days every 2nd month for long periods.

Contra-Indications

Iron & Lead poisoning.

Special Precautions

Hypertension, hepatic damage. Antihistaminics given 1/2 hrs. before reduces intensity of adverse effects.

Side Effects

Rise in BP, tachycardia, vomiting, tingling and burning sensation, inflammation of mucous membranes, sweating, cramps, headache & anxiety.

Drug Interactions

None reported