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ETODOLAC

ETODOLAC

It is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities.

Indications

It is indicated in Osteoarthritis : for acute and long-term use, Rheumatoid arthritis: for acute and long-term use, Acute painful conditions.


Dosage

Starting dose: 300mg 2 or 3 times/day or 400 or 500mg twice daily. Maintenance dose : A lower dose of 600mg/day may suffice for long-term administration.


Contra-Indications

Hypersensitivity, asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery. Active peptic ulcers or GI bleeding severe renal impairment.


Special Precautions

CHF, hypertension, dehydration, decrease renal or hepatic function, history of GI disease (bleeding, ulcers or previous GI symptoms with NSAID use, or those receiving anticoagulants and/or corticosteroids.


Side Effects

Adbominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heatburn, nausea, GI ulcers (gastric/duodenal), vomiting. Other events including : abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headache, increased bleeding time, pruritis, rashes, tinnitus.


Drug Interactions

A blood thinner such as warfarin (Coumadin) Cyclosporine (Gengraf, Neoral, Sandimmune) Digoxin (Lanoxin) Lithium (Eskalith, Lithobid) Methotrexate (Rheumatrex, Trexall) A diuretic (water pills) such as furosemide (Lasix) Steroids (prednisone and others)


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