HYALURONIDASE

It is an enzyme which depolymerises hyaluronic acid, a background substance in connective tissue which prevents the spread of foreign substances e.g. bacteria, drugs. By combing an injection with hyaluronidase drug spreads rapidly over a wide area and so is absorbed more quickly. When an i.v. injection of an irritant drug has accidentally leaked into perivenous tissue and there is pain, or risk of damage to another structure, hyaluronidase and saline may be injected locally to dilute the irritant and to hasten its absorption.

Indications

For promotion of diffusion of fluids at subcutaneous and i.m. injection sites.

Contra-Indications

Hypersensitivity

Special Precautions

Impaired renal function. Conduct sensitivity test prior to administration.

Side Effects

Cardiac fibrillation, urticaria, hypersensitivity and anaphylaxis.

Drug Interactions

Heparin and aminoglycoside inhibit the enzyme, salicylates and NSAIDs inhibit the spreading action. Increases diffusion of local anaesthetics. Action potentiated by urokinase especially in the treatment of myocardial infarction.