Idarubicin
Idarubicin hydrochloride is a DNA-interacalating analog of daunorubicin which has an inhibitory effect on nucleic acid synthesis and interacts with the enzyme topoisomerase II. It belongs to anthracylic antineoplastic group.Acute myeloid leukemia (AML).
Intravenous; 12mg/m2 daily for 3 days by slow (10 to 15 min) along with cytarabine.
Hypersensitivity.
Paediatric: Safety not established. Pregnancy: Category D; Not safe in pregnancy. Lactation: Not know if secreted in milk. Elderly: Increased incidence of side effects like congestive heart failure, serious arrhythmias, chest pain, myocardial infarction, and asymptomatic decline in LVEF more frequently than younger patients.
Infection, Nausea & vomiting, Hair loss, abdominal cramps/Diarrhea, hemorrhage, Mucositis, dermatologic, headache, cardiac, neurologic-peripheral nerves, Pulmonary Allergy, Seizure.
Brand Name | Manufactured by |
---|---|
IDARUBICIN HYDROCHLORIDE | KWALITY PHARMACEUTICALS LTD |
ZAVEDOS | PFIZER LTD. |