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Idarubicin

Idarubicin

Idarubicin hydrochloride is a DNA-interacalating analog of daunorubicin which has an inhibitory effect on nucleic acid synthesis and interacts with the enzyme topoisomerase II. It belongs to anthracylic antineoplastic group.

Indications

Acute myeloid leukemia (AML).


Dosage

Intravenous; 12mg/m2 daily for 3 days by slow (10 to 15 min) along with cytarabine.


Contra-Indications

Hypersensitivity.


Special Precautions

Paediatric: Safety not established. Pregnancy: Category D; Not safe in pregnancy. Lactation: Not know if secreted in milk. Elderly: Increased incidence of side effects like congestive heart failure, serious arrhythmias, chest pain, myocardial infarction, and asymptomatic decline in LVEF more frequently than younger patients.


Side Effects

Infection, Nausea & vomiting, Hair loss, abdominal cramps/Diarrhea, hemorrhage, Mucositis, dermatologic, headache, cardiac, neurologic-peripheral nerves, Pulmonary Allergy, Seizure.


Other Brands With Same Generic
Brand Name Manufactured by
IDARUBICIN HYDROCHLORIDE KWALITY PHARMACEUTICALS LTD
ZAVEDOS PFIZER LTD.
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