IMMUNE GLOBULIN INTRAVENOUS (HUMAN)

Dosage

Primary ID -0.2-0.8 g/kg (usually 0.4 g/kg) given once in 3-4 weeks. A trough serum level of 5g/L should be maintained. Secondary ID -0.2-04 g/kg every 3 or 4 weeks; Allograft bone marrow receipients - 9.5g/kg every week for 3 months starting 7 days before transplant. Then monthly for 9 months; ITP -0.4 g/kg/day for the first 5 days or 0.4-1g/kg on 2 days. Follow up with 0.4 g/kg given every 1-4 weeks; Severe infections - 0.4-1.0 g/kg daily for 1-4 days; Kawasaki syndrome -1.6-2.0 g/kg in divide

Contra-Indications

Hypersensitivity, lgA-deficient patients known to have antibodies to lgA.

Special Precautions

Patients with agammaglobulinaemia or severe hypogammaglobulinaemia, Monitoring of serum creatinine.

Side Effects

Headache, hyperthermia, nausea, vomiting, abdominal pain, diarrhoea, fatigue, malaise, dizziness, chills, sweating, cyanosis, dyspnoea, feeling of fightness or pain in the chest, back pain, myalgia, rigor, flushing or pallor, hypertension, hypotension and tachycardia.

Drug Interactions

Do not mix with any other medication.