Mesalamine

Mesalamine, also known as 5-aminosalicylic acid (5-ASA), is a medication belonging to the class of aminosalicylates. It is commonly used in the treatment of inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease. Mesalamine works locally in the gastrointestinal tract to reduce inflammation.

Indications

Mesalamine is indicated for the treatment of mild to moderate ulcerative colitis and as a maintenance therapy to prevent relapse. It is also used in the management of mild to moderate Crohn's disease involving the colon and the terminal ileum.

Dosage

Dosage may vary depending on the specific formulation of mesalamine (oral, rectal, or topical) and the severity of the condition. It is important to follow the prescribed dosage and administration instructions provided by the healthcare provider.

Contra-Indications

Mesalamine is contraindicated in individuals with a known hypersensitivity to salicylates, a history of allergic reactions to sulfasalazine, or other components of the formulation. Patients with severe renal impairment or hepatic dysfunction may also be advised against its use.

Special Precautions

-Patients with pre-existing renal impairment or liver disease should be closely monitored during mesalamine therapy. -Mesalamine should be used with caution in patients with a history of cardiac disease. -Caution is advised in patients with a known hypersensitivity to aspirin or other NSAIDs. -Blood cell counts and renal function should be regularly monitored.

Side Effects

Common side effects of mesalamine may include headache, nausea, abdominal pain, diarrhea, and rash. Serious but rare side effects may include pancreatitis, myocarditis, and interstitial nephritis.

Drug Interactions

There may be potential interactions between mesalamine and medications such as azathioprine, 6-mercaptopurine, or other drugs that affect renal function. It is essential to inform the healthcare provider of all medications being taken.