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Monobenzone is a depigmenting agent whose mechanism of action is not fully understood. The topical application of monobenzone in animals, increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone may cause the destruction of melanocytes and permanent depigmentation. This effect is erratic and may take one to four months to occur while existing melanin is lost with normal sloughing of the stratum corneum. Hyperpigmented skin appears to fade more rapidly than normal skin, and exposure to sunlight reduces the depigmenting effect of the drug. The histology of the skin after depigmentation with topical monobenzone is the same as that seen in vitiligo; the epidermis is normal except for the absence of identifiable melanocytes. A thin layer of Monobenzone Cream 20% should be applied and rubbed into the pigmented area two or three times daily,The adverse effects are Mild, transient skin irritation and sensitization, including erythematous and eczematous reactions have occurred following the topical application of Monobenzone Cream 20%. Although those reactions are usually transient, treatment with Monobenzone Cream 20% should be discontinued if irritation, a burning sensation, or dermatitis occurs. Areas of normal skin distant to the site of Monobenzone Cream 20% application frequently have become depigmented, and irregular, excessive, unsightly, and frequently permanent depigmentation has occurred. Monobenzone is a depigmenting agent used topically to lighten the skin. It works by inhibiting melanin production, leading to depigmentation of the skin.


Monobenzone cream is primarily indicated for the treatment of conditions causing hyperpigmentation, such as vitiligo. It is used to lighten the skin affected by these conditions.


Apply a thin layer of Monobenzone cream to the affected areas of the skin, usually twice daily or as directed by a healthcare professional. It is essential to follow the prescribed dosage and application instructions.


Monobenzone cream should not be used by individuals with a known hypersensitivity to monobenzone or any of the cream's components. It is also contraindicated in patients with ochronosis.

Special Precautions

-Avoid contact with eyes, nose, mouth, and other mucous membranes. -Sunscreen should be used alongside Monobenzone to prevent increased sensitivity to sunlight. -Consult a healthcare professional before use during pregnancy or breastfeeding.

Side Effects

Common side effects may include itching, redness, or irritation at the application site. Serious side effects are rare but may include allergic reactions. Discontinue use and seek medical attention if any severe reactions occur.

Drug Interactions

No significant drug interactions are reported with Monobenzone cream. However, it is advisable to inform the healthcare professional about all medications being used, including over-the-counter drugs and herbal supplements.

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