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Prasugrel is used with aspirin by patients with heart disease (recent heart attack, unstable angina) who undergo a certain heart procedure (angioplasty). This medication helps to prevent other serious heart/blood vessel problems (such as heart attacks, strokes, blood clots in stents). It works by blocking platelets from sticking together and prevents them from forming harmful blood clots. This "anti-platelet" effect helps to keep blood flowing smoothly in your body.


It is a novel platelet inhibitor for acute coronary syndromes planned for percutaneous coronary intervention (PCI).


The recommended dose of prasugrel is a 60mg oral loading dose followed by a maintenance dose of 10mg orally daily, which should be administered with concomitant aspirin 75-325mg orally daily. For patients weighing


Active pathological bleeding (peptic ulcer or ICH) previous (TIA) or stroke. Anticipated coronary artery bypass graft (CABG) surgery within 7 days. Age of >75yrs, unless patient is deemed at high risk of recurrent ischemic events (diabetes DM or prior MI). Recent fibrinolytic therapy. Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) or cyclooxygenase-2 (COX-2) inhibitors other than daily aspirin, warfarin therapy, Anti-platelet therapy, severe hepatic impairment.

Special Precautions

Prasugrel should be discontinued for active bleeding, elective surgery, TIA or stroke. Interruption or premature discontinuation of anti-platelet medications has been associated with an increased risk of stent thrombosis, Ml, and death. Advanced age (>75yrs), Low body weight (

Side Effects

Bruising, Headache Disorder, Hyperlipidemia, Hypertension, Anemia, Atrial Fibrillation, Back pain, Bradycardia, chest pain, cough, diarrhea, dizziness, dyspnea, fatigue, gastrointestinal hemorrhage, hemorrhage, hypotension, nausea, pain, peripheral edema, abnormal hepatic function tests, angioedema, epistaxis, fever, hematoma, hypersensitivity drug reactions, intracranial bleeding, leukopenia, retinal hemorrhage, thrombocytopenic disorder, thrombotic thrombocytopenic purpura.

Drug Interactions

Aspirin, fiber therapy, fish oil (omega-3 polyunsaturated fatty acids) furosemide, Atorvastatin, Lisinopril, Loratadine, Metoprolol, nitroglycerin, Levothyroxine, Ubiquinone, Isosorbide mononitrate.

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