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It belongs to the class of SSRI (selective serotonin reuptake inhibitors) drug but is unrelated to other SSRIs. It is chemically unrelated to tricyclic, tetracyclic depressants. The mechanism of action is inhibition of CNS neuronal uptake of serotonin (5HT).


Major depressive disorder. Obsessions and compulsion in patients with obsessive-compulsive disorder (OCD), panic disorder.


In depression & OCD: 50 mg once daily. Panic disorder: Initially 25 mg once daily and after 1 week 50 mg daily. Maximum dosage: 200 mg/day.


Hypersensitivity, liver disease, MAOIs.

Special Precautions

Stop MAOI therapy at least 2 week prior to starting of sertraline. Renal/hepatic impairment, acute coronary syndromes, seizure disorders, concomitant use of alcohol. Paediatrics: Safety below 16 yrs not established. Pregnancy: Use if potential benefits outweigh the risk. Lactation: Use with cautions. Elderly: No special risk.

Side Effects

Dry mouth, nausea, stomach upset, diarrhoea, tremor, sweating, dizziness, sleeplessness, indigestion.

Drug Interactions

Warfarin, digoxin, cimetidine, lithium, MAOIs, tricyclic antidepressants, hypoglycaemic drugs, antipyrine, alcohol.

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