SODIUM HEPARINATE
Sodium heparinate is an anticoagulant medication derived from heparin, a natural substance found in the body. It works by preventing blood clotting and is used in various medical situations where the risk of clot formation is high.-Prophylaxis and treatment of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE). -Prophylaxis of arterial thromboembolism. -Used during surgeries and medical procedures such as cardiac surgery, dialysis, and angioplasty to prevent clot formation. -Treatment of disseminated intravascular coagulation (DIC). -Management of acute coronary syndrome.
-The dosage of sodium heparinate varies depending on the indication and the patient's weight and clinical condition. -For prophylaxis of VTE, the dose is typically lower (e.g., 5000 units subcutaneously every 8–12 hours). -For treatment of VTE or other conditions, higher doses are often required. -Dosage may be adjusted based on coagulation monitoring (e.g., aPTT or anti-Xa levels). -Always follow the healthcare provider's instructions and monitor blood coagulation regularly.
-Hypersensitivity to heparin or its components. -Active bleeding disorders (e.g., peptic ulcer, hemorrhagic stroke). -Severe thrombocytopenia (low platelet count). -Certain conditions affecting blood coagulation, such as hemophilia. -Known or suspected intracranial bleeding.
-Careful monitoring is necessary, especially in patients with renal or hepatic impairment. -Caution in elderly patients and those with bleeding disorders. -Avoid intramuscular injections to prevent hematoma formation. -Monitor blood counts, including platelet count, regularly. -Dose adjustments may be needed in patients with a high risk of bleeding.
-Bleeding is the most common side effect, which may manifest as nosebleeds, bleeding gums, or easy bruising. -Thrombocytopenia (decrease in platelet count). -Osteoporosis (with long-term use). -Elevated liver enzymes. -Hypersensitivity reactions (e.g., rash, hives).
-Other anticoagulants and antiplatelet drugs may increase the risk of bleeding. -Certain medications such as NSAIDs, aspirin, and some antibiotics may interact with sodium heparinate. -Herbal supplements such as garlic and ginkgo may also affect the risk of bleeding.
