Trifluoperazine, Fluphnazine, Thioproperazine
These are high potency piperazine side chain phenothiazines. They have minimum autonomic actions; hypotension & sedation are not significant. They are less likely to cause jaundice, hypersensitivity reactions & precipitate seizure in epileptics.Hallucinations, schizophrenia, mania, delusions, agitation, organic brain syndrome, tension headache.
Comatose or severely depressed states. Blood dyscarasias, hepatic or renal impairment.
Intestinal obstruction, cardiovascular disease, epilepsy, glaucoma, pregnancy, lactation, pheochromocytoma. Suspected or established brain damage.
Dry mouth, constipation, difficulty in urination, agitation, insomnia, depression, convulsions, E.C.G. changes, tachycardia, hypotension. Extrapyramidal reactions, drowsiness.
Potentiates other CNS depressants. Orthostatic hypotension with MAOIs. Reverse antihypertensive effect of guanethidine, methyldopa and clonidine.Reduced bioavailability with antacids.
