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Levocetirizine Hydrochloride

Levocetirizine Hydrochloride

It is a selective, long acting peripheral H1 receptor antagonist antihistamine. The increased polarity of Levocetrizine may decrease distribution of the drug into the CNS, resulting in reduced potential for adverse CNS effects. Tolerance doesnot occur. As it does not readily cross the blood brain barrier, it does not cause sedation or interfere with mental alertness or memory function.

Indications

Seasonal allergic rhinitis, perennial allergic rhinitis, ocular symptom (redness, lacrimation and itching), chronic idiopathic urticaria, urticaria dermographism, atopic eczema and contact dermatitis, also in acute allergic reactions due to drugs, food and insect bites.


Dosage

Adults and childern above 6 years : 5mg single intake orally. Children below 6 years: No adjusted dose. Elderly : Adjust dose on the basis of renal function. Pregnancy : use with caution. Lactation : use with caution as secreted in breast milk.


Contra-Indications

In severe renal impairment.


Special Precautions

Patients intending to drive/operate machinery or ingage in potentially hazardons activities should be warned not to take more than the recommended dose. Concurrent use with alcohol or other CNS depressant may cause reduction in alertness and impairment of performance. To be used cautionsly in pregnancy lactation and children below 6 years of age.


Side Effects

Although well tolerated some effects are headache, somnolence, dry mouth, mild drowsiness and G.I. disturbances


Drug Interactions

Rate of absorption is reduced with food. Alcohol and CNS depressants may potentiate CNS side effects in sensitive patients.


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