Abacavir SulphateIt is a carbocyclic synthetic nucleoside analogue. Intracellularly, it is converted by cellular enzymes to the active metabolite, carbovir triphosphate. Carbovir triphospahte inhibitis the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. The lack of a 3-OH group in the incorporated nucleoside analogue prevents the formation of the 5 to 3 phosphodiester linkage essential for DNA chain elongation and therefore, the viral DNA growth is terminated..
In combination with other antiretroviral agents for the treatment of HIV-1 infections.
Adults : 300mg twice daily in combination with other antiretrovirals. Adolescent and paediatric patients: Dosage for patients between 3 months to 16 years is 8mg/kg twice daily (up to a maximum of 300mg twice daily).
It has been associated with fatal hypersensitivity reactions. Hence should not be restarted after any hypersensitivity reaction occurs with abacavir..
Should always be used in combination with other antiretroviral agents.
Hypersensitivity reactions (fever, skin, rash, fatigue, nausea, vomiting, diarrhoea or abdominal pain pharyngitis, dyspnoea or cough).
Ethanol, no clinically significant effect with methadone.