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Aceclofenac with Rabeprazole

Aceclofenac with Rabeprazole

Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic properties. Rabeprazole is a proton pump inhibitor (PPI) that reduces the production of stomach acid.


This combination is commonly prescribed for the management of inflammatory conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The addition of Rabeprazole helps prevent NSAID-induced gastric ulcers.


The recommended dosage may vary based on the patient's condition, medical history, and response to treatment. It is crucial to follow the prescribing physician's instructions.


This combination is contraindicated in individuals with a history of hypersensitivity to Aceclofenac, Rabeprazole, or other NSAIDs/PPIs. It is also contraindicated in patients with a history of gastrointestinal bleeding, severe hepatic impairment, or renal failure.

Special Precautions

-Caution is advised in patients with a history of cardiovascular diseases, renal impairment, or peptic ulcers. -Monitoring of liver function and blood parameters is essential during prolonged therapy .-Avoid concurrent use with other NSAIDs or anticoagulants unless directed by a healthcare professional.

Side Effects

Common side effects may include gastrointestinal disturbances (nausea, dyspepsia), headache, dizziness, and skin rash. Serious side effects such as gastrointestinal bleeding or cardiovascular events may occur and should be reported to a healthcare provider immediately.

Drug Interactions

-Concomitant use with other NSAIDs or corticosteroids may increase the risk of adverse effects. -Anticoagulants, antiplatelet drugs, and selective serotonin reuptake inhibitors (SSRIs) may enhance the risk of bleeding. -Monitoring is recommended when combining with medications like methotrexate or lithium.

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