Activated Polydimethylsiloxane

Activated Polydimethylsiloxane, commonly known as APDMS, is a medical-grade silicone derivative used in various pharmaceutical and healthcare applications. It is renowned for its inert nature and high adsorption capacity, making it suitable for gastrointestinal conditions and other medical uses.

Indications

APDMS is indicated for the treatment of gastrointestinal disorders such as acid reflux, gastritis, and peptic ulcers. It works by adsorbing excess gastric acid and forming a protective barrier on the mucosal lining, thereby alleviating symptoms and promoting healing.

Dosage

The dosage of APDMS varies depending on the severity of the condition and the formulation used. Typically, it is administered orally as tablets or suspensions. The recommended dosage should be followed as per healthcare provider's instructions.

Contra-Indications

APDMS is contraindicated in patients with known hypersensitivity to silicone or any component of the formulation. It should not be used in cases of intestinal obstruction or perforation due to the potential risk of complications.

Special Precautions

Special precautions should be taken in patients with renal impairment, as APDMS can potentially accumulate in the body. Monitoring of renal function may be necessary during prolonged therapy. It is also advised to avoid concurrent administration with other medications without consulting a healthcare professional.

Side Effects

Common side-effects of APDMS include mild gastrointestinal discomfort such as nausea, bloating, or constipation. These symptoms are usually transient and resolve with continued use or dose adjustment.

Drug Interactions

There are no significant drug interactions reported with APDMS. However, it is advisable to separate the administration of APDMS from other medications to prevent potential interactions or interference with their absorption.