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Alendronate Sodium- Drug Interactions, Dosage, Side Effects, indications, Uses and Precautions

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Alendronate Sodium

Alendronate Sodium

Alendronate sodium is a bisphosphonate medication used to treat and prevent osteoporosis in postmenopausal women and men. It is also used to treat osteoporosis caused by long-term steroid use and Paget's disease of bone. The drug works by inhibiting osteoclast-mediated bone resorption, leading to an increase in bone mass and strength. It is a third generation bisphosphonate, with a high potential in the treatment of postmenopausal osteoporosis. The bisphonates does not undergo enzymatic degradation by skeletal pyrophosphatases and persists in the skeleton prolonged periods.

Indications

-Osteoporosis in postmenopausal women and men -Osteoporosis caused by long-term glucocorticoid use -Paget's disease of bone


Dosage

-Osteoporosis: Adults: 10 mg daily or 70 mg once a week. -Paget's disease: Adults: 40 mg daily for six months.


Contra-Indications

-Esophageal abnormalities (such as strictures or achalasia) -Inability to stand or sit upright for at least 30 minutes after taking the medication -Hypocalcemia -Hypersensitivity to alendronate or any component of the formulation


Special Precautions

Patient with acute upper gastrointestinal problem. Hypocalceamia, causes of oesteoporosis. Paediatrics: Should not be given. Pregnancy: Should not be given. Lactation: Should not be given. Elderly: Greater sensitivity to Alendronate.


Side Effects

Abdominal pain, nausea, dyspepsia, consipation, diarrhoea, oesophageal ulcer, faltulence, acid regurgitation, vomiting, dysphagia, abnormal distention, headache, musculoskeletal pain.


Drug Interactions

Calcium supplements and antacids may interfere with the absorption of Alendronate. Aspirin containing compounds may increase the incidences of GI side effects.


Other Brands With Same Generic
Brand Name Manufactured by
ADC-10 RADIX
ALENDIX VINTAGE LABS PVT. LTD.
Other Combination Brands
Brand Name Manufactured by
ADC-D3 RADIX
DEVBONE-D DEVAK FORMULATIONS
Goldcal- Alen RONYD HEALTHCARE (P) LTD.

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