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Alprazolam

Alprazolam

It is a triazolo analogue of benzodiazepine, which is indicated as an anti-anxiety drug in various disorders associated with anxiety. Drug has a dose related depressant effect on central nervous system varying from mild impairment of task performance to hypnosis.

Indications

Anxiety disorders and short term relief of symptoms of anxiety. Anxiety associated with depression.


Dosage

Starting dose is 0.25-0.5 mg 3 times daily. Max 3-4 mg daily in divided doses.


Contra-Indications

Hypersensitivity to benzodiazepines. Acute narrow angle glaucoma.


Special Precautions

C.N.S. depressants. Paediatrics: Not recommended. Pregnancy: Contraindicated. Lactation: Contraindicated. Elderly: Dose should be reduced.


Side Effects

Drowsiness or light headedness, withdrawal seizures, anorexia, transient amnesia or memory impairment, loss of coordination, slurred speech, musculo skeletal weakness, pruritus.


Drug Interactions

Cimetidine, fluoxetine, ketoconazole, itraconazole reduces the clearance hence dose should be reduced to one third. Alprazolam enhances action of Imipramine and desipramine. Potentiates action of alcohol and CNS depressants.


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