AmantadineIt is chemically unique (a tricycline amine) and unrelated to any nucleic acid precursor. It inhibits replication of influenza virus (a myxovirus) at an early stage of the process (probably uncoating of viral nucleic acid).
Prophylaxis and treatment of influenza A. Parkinsonism.
Adults: 100 mg 12 hrly for 5-7 days. Children: 5 mg/kg body wt daily.
Epilepsy and other C.N.S disease, gastric ulcer.
Earlier the drug is started, the better.
Insomnia, dizziness, lack of mental concentration, hallucinations, postural hypotension, ankle edema due to local vasoconstriction.
Enhances the adverse effects of antimuscarinic agents and levodopa. Thioridazine increases the tremors in Parkinsonium. Enhance effects of benzhexol, orphenedrine. Triamterene and hydrochlorothiazide increases the plasma amantadine levels.
|Brand Name||Manufactured by|
|COMANTREL||CONSERN PHARMA (P) LTD.|