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(Codeine, Diphenoxylate-atropine, Loperamide) Diphenoxylate+Atropine : It is an opioid, chemically related to pethidine; used exclusively as constipating agent; action similar to codeine. The antidiarrhoeal action is most prominent, but CNS effects do occur. Atropine is added in non pharmacological dose to discourage abuse.


Symptomatic relief of diarrhoea.


2.5-5 mg 6 hrly. Children over 6 yrs:0.25 mg of diphenoxylate/kg body wt.daily in divided doses.


Children below 6 yrs, jaundice, pseudomembranous colitis. Atropine intolerance, diphenoxylate allergy.

Special Precautions

Hepatic disorders, pregnancy, lactation, ulcerative colitis, electrolyte imbalance & oral rehydration to be checked.

Side Effects

Nausea, vomiting, abdominal discomfort, anorexia, drowsiness, dizziness, headache, depression, euphoria, allergy, lethargy.

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