Apomorphine

Apomorphine is a dopamine agonist used primarily in the treatment of Parkinson's disease and occasionally for erectile dysfunction. It acts on the dopamine receptors in the brain, helping to manage symptoms related to these conditions.

Indications

-Parkinson's Disease: Used to manage motor symptoms, particularly in advanced stages of the disease. -Erectile Dysfunction: Occasionally used in cases where other treatments are ineffective.

Dosage

-Parkinson's Disease: Typically administered subcutaneously. Dosage is individualized based on the patient's response and tolerance, usually starting with lower doses and gradually increasing. -Erectile Dysfunction: Administered via subcutaneous injection, with dosing tailored to the individual's needs.

Contra-Indications

-Hypersensitivity: Known allergy to Apomorphine. -Severe Cardiovascular Diseases: Including significant hypotension or severe coronary artery disease. -Severe Hepatic or Renal Impairment: Patients with significant liver or kidney dysfunction.

Special Precautions

-Orthostatic Hypotension: Risk of sudden drop in blood pressure when standing up. -Mental Health: Monitor for changes in mood or behavior. -Pregnancy and Lactation: Use only if the potential benefits outweigh the risks.

Side Effects

-Common: Nausea, vomiting, dizziness, and headache. -Serious: Hallucinations, severe hypotension, dyskinesia, and sudden onset of sleep.

Drug Interactions

-Antihypertensives: May potentiate the effects of blood pressure-lowering medications. -Dopaminergic Drugs: Other dopamine agonists may interact. -Antiemetics: May reduce the effectiveness of Apomorphine.