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Apremilast, is an analog of thalidomide, acts as a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4) and inhibits spontaneous production of TNF-alpha from human rheumatoid synovial cells.


Adult patients with active psoriatic arthritis, moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy.


Oral; 10-30 mg vary according to initial or maintenance dose.


Known hypersensitivity.

Special Precautions

Paediatric: Data not sufficient. Pregnancy: Category C. Lactation: Data not sufficient. Elderly: use with caution

Side Effects

Diarrhea,Nausea,Headache, Upper respiratory tract infection, Vomiting, Nasopharyngitis,Abdominal pain upper, depression.

Drug Interactions

Strong CYP450 inducers such as rifampicin.

Ad 5