Atorvastatin
Atorvastatin acts by competitively inhibiting 3-hydroxy-3-methyl glutaryl co-enzyme A (HMGCoA) reductase, an enzyme involved in cholesterol synthesis.Primary hypercholesterolaemia, heterozygous familial hypercholesterolaemia, homozygous familial hypercholesterolaemia or combined hyperlipidaemia.
Initially :10mg daily. May be increased upto 80mg once daily.
Hyeprsensitivity, active liver disease, Pregnancy and lactaion.
Patients with history of liver disease or high alcohol intake. Unexplained muscle pain, tenderness or weakness.
GI effects like abdominal pain, nausea and vomiting. Reversible myositis, headache, altered LFTs, insomnia, anorexia, alopecia, impotence, chest pain, hypoglycaemia and hyperglycaemia.
Antacids, colestipol, digoxin, erythromycin.
