Atorvastatin with Ezetimibe

Atorvastatin and Ezetimibe are hypolipidamic agents. Both have a different mode of action, which is often necessary to achieve a desired satisfactory reduction in lipid levels.

Indications

Primary hypercholesterolemia, homozygous, familial hypercholesterolemia, homozygous sitosterolemia, heterozygous familial hypercholesterolemia, combined hyperlipidaemia, hyperlipoproteinaemia, hypertriglyceridaemia, hyperlipidaemia associated with hypertension and type II diabetes.

Dosage

Atorvastatin 10mg and Ezetimibe 10mg orally once daily.

Contra-Indications

Hypersensitivity, active liver disease, pregnancy, lactation, paediatrics.

Special Precautions

Hepatic insufficiency, high alcohal intake, unexplained muscular pain, tenderness, or weakness, mutagenesis, carcinogenesis. Impairment of infertility.

Side Effects

Anorexia, nausea, vomiting, abdominal pain, headache, insomnia, reversible myositis, chest pain, alopecia, impotence, altered LFTs, hyperglycaemia, hypoglycaemia.

Drug Interactions

Antacids, colestipol, digoxin, erythromycin.