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Bempedoic acid is a medication used in the management of hypercholesterolemia, a condition characterized by elevated levels of cholesterol in the blood. Below is a comprehensive overview of various aspects related to bempedoic acid Bempedoic acid is a first-in-class, oral ATP citrate lyase inhibitor that works by blocking a key enzyme in the cholesterol synthesis pathway. This inhibition ultimately leads to a decrease in cholesterol production in the liver.


Bempedoic acid is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia (HeFH) or established atherosclerotic cardiovascular disease (ASCVD) who require additional lowering of LDL cholesterol.


-The recommended dosage of bempedoic acid is typically 180 mg once daily, administered orally with or without food. -Oral; 180 mg once a daily


Bempedoic acid is contraindicated in patients with a history of a serious hypersensitivity reaction to bempedoic acid or its components. It is also contraindicated in patients with active liver disease or unexplained persistent elevations of serum transaminases.

Special Precautions

-Caution should be exercised in patients with a history of gout, as bempedoic acid may exacerbate this condition. Liver function should be monitored regularly, and therapy should be discontinued if persistent elevations of liver enzymes occur. -Monitor potassium levels. Paediatric: Safety and efficacy in pediatric patients have not been established Pregnancy: Data not sufficient Lactation: Data not sufficient Elderly: Data not sufficient.

Side Effects

Upper respiratory tract infection, muscle spasms, high levels of uric acid in the blood, back pain, abdominal pain or discomfort, bronchitis, pain in the extremities, anemia, and elevated liver enzymes, sudden pain, swelling, bruising, or tenderness, stiffness, movement problems or a snapping or popping sound in any of the joints (rest the joint till further medical care is received), severe foot or toe pain, joint pain or swelling, warmth or redness over the joints; or low red blood cells (anemia)- pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.

Drug Interactions

Bempedoic acid may interact with other medications, including those metabolized by cytochrome P450 enzymes. Statins and other medications that may increase the risk of myopathy or rhabdomyolysis should be used with caution when co-administered with bempedoic acid.

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