Cefpodoxime Proxetil

It is a bactericidal and kills bacteria by interfering with the synthesis of the bacterial cell wall. It is stable in the presence of beta lactamase enzyme, a number of beta lactamase producing organisms resistant to penicillin/other cephalosporins are likely to be susceptible to cefpodoxime.

Indications

URTI including pharyngitis and tonsilitis: 100 mg bid for 5-10 days. Acute exacerbation of chronic bronchitis: 200 mg bid for 10 days. Acute community acquired pneumonia: 200 mg bid for 14 days. Actue uncomplicated gonorrhoea: 200 mg single dose. Uncomplicated urinary tract infection: 100 mg bid for 7 days. Skin and skin structure infections: 400 mg bid for 7 to 14 days

Dosage

Oral dosage (tablets only) Adults, Adolescents, and Children >= 12 years 200 mg PO every 12 hours for 10 days.

Contra-Indications

Hypersensitivity.

Special Precautions

Penicillin senstitive patients. For patients with severe renal impairment the dosing interval is to be prolonged to 24 h. In patients maintained on haemodialysis, dose frequency to be adjusted to 3 times a week after hemodialysis. Paediatrics: Safety and efficacy in infants less than 5 months of age have not been established. Pregnancy: Avoid during pregnancy unless there are compelling clinical indications.

Side Effects

Diarhoea, nausea, vomiting, abdominal pain, colitis and headache.

Drug Interactions

Antacids decreases the peak plasma levels, oral anticholinergics delay the attainment of peak plasma level. Probenecid inhibits renal excretion.