Ceftriaxone Sodium

Ceftriaxone Sodium is a broad-spectrum cephalosporin antibiotic that is effective in treating a variety of bacterial infections. It works by inhibiting the synthesis of bacterial cell walls, ultimately leading to the death of bacteria. Ceftriaxone is commonly administered via injection (intravenous or intramuscular) and is known for its long half-life, allowing for once-daily dosing.

Indications

Ceftriaxone is used to treat various bacterial infections, including: Respiratory tract infections Skin and soft tissue infections Urinary tract infections Bone and joint infections Infections of the abdominal cavity (peritonitis) Gonorrhea and other sexually transmitted infections

Dosage

The dosage of Ceftriaxone varies depending on the severity and type of infection, as well as the patient's age and medical history. Typically, for adults, the dosage ranges from 1 to 2 grams per day, while for children, the dosage ranges from 50 mg/kg to 75 mg/kg daily, up to a maximum of 2 grams per day. Treatment duration varies based on the infection being treated. Dosage and administration should be determined by a healthcare professional.

Contra-Indications

Ceftriaxone should not be used in individuals with a known allergy to cephalosporin antibiotics. Additionally, it is contraindicated in neonates who require treatment with calcium-containing IV solutions, as it may cause precipitation in the lungs and kidneys.

Special Precautions

Renal and Hepatic Impairment: Dose adjustment may be required for patients with renal or hepatic impairment. Caution in Neonates: As mentioned, Ceftriaxone should not be used in neonates who require calcium-containing IV solutions. Prolonged Use: Long-term use may result in the overgrowth of non-susceptible organisms, including fungi.

Side Effects

Diarrhea Rash Nausea Vomiting

Drug Interactions

Ceftriaxone may interact with other medications, including: Calcium-containing IV solutions, especially in neonates. Warfarin, as it may enhance its anticoagulant effect. Oral contraceptives, potentially reducing their efficacy. Certain other antibiotics or drugs that affect renal function.