Cefuroxime
It is resistant to most beta-lactamases and is active against a wide range of Gram-positive and Gram-negative organisms. The most important use of cefuroxime is in meningitis caused by H. influenzae, meningococci and pneumococci, because it attains high concentrations in C.S.F.Respiratory tract, Genito-urinary tract, Skin and soft tissue infections. Gonorrhoea, acute gonococcal urethritis and cervicitis Meningitis, Prophylaxis against infections in surgical procedures.
Adults: 750 mg thrice daily i.m or i.v. Severe Infections :1.5 gm thrice daily i.v. Total dose 3-6 gm daily. Infants and Children : 30-100 mg/kg body wt daily in 3-4 divided doses. Neonates:30-100mg/kg body wt in 2-3divided doses. Meningitis : 200-240mg/kg body wt i.v. daily in 3-4 divided doses. Neonates : 100mg/kg body wt i.v. daily.
Patients with known hypersensitivity to cephalosporin antibiotics.
Anaphylactic reaction to penicillins. Pseudomembranous colitis. Overgrowth of non-susceptible organisms. Paediatrics: Not safe in children below 3 months. Pregnancy: Use with caution. Lactation: Use with caution.
Skin rashes, Eosinophilia and transient increase of hepatic enzymes.
Synergy with aminoglycosides
