DEFERIPRONE
It moves throgh the body excretion primary in the urine.In transfusion hemosiderosis in patients with thalassaemia, other hemolytic anemias, aplastic anemias, mylodysplastic syndromes, acute iron poisoning, siderosis, associated with liver cirrhosis, for the diagnosis of iron storage disease.
Adults and children to achieve negative iron balance: 50-100mg/kg/day in 2-4 divided doses. A total daily dose above 100g/kg/day is not recommended.
Hypersensitivity, neutropenia, agranulocytosis, pregnancy and lactation.
Monitor serum ferritin concentrations or other indications of body iron load every two to three months. Stop therapy if serum ferritin measurements fall below 500mg/L. Monitor liver enzymes levels.
Reddish/browned colored urine which is a harmless side effect, nausea, vomiting, gastrointestinal distress, joints pian, hepatotoxicity.
