Diloxanide Furoate

It is highly effective luminal amoebicide: directly kill trophozoites responsible for production of cysts. No systemic antiamoebic activity is evident despite its absorption. Diloxanide furoate exerts no antibacterial action. It is less effective in invasive amoebic dysentery, probably because of a poor tissue amoebicidal action. It has produced high cure rates in mild intestinal amoebiasis and in a symptomatic cystpassers.

Indications

Intestinal amoebiasis.

Dosage

500 mg thrice daily. Children 20 mg/kg body wt daily in divided doses. All for 5-10 days.

Contra-Indications

Not to be used in systemic amoebiasis

Special Precautions

Pregnancy & Lactation: Use with caution.

Side Effects

Flatulence, occasional nausea, itching, early urticaria.

Drug Interactions

None reported.