Doxofylline

Methylxanthines are phosphodiesterase inhibitors. Doxofylline is a new generation long acting oral methylxanthine derivative.

Indications

For maintenance therapy in patients suffering with Asthma and Chronic Obstructive Pulmonary Disease (COPD).

Dosage

Adult:400mg once a day. Single dose administration in the evening reduces nocturnal symptoms and helps to keep the patients complaint free during the day. However,in certain cases 400mg twice daily is recommended on the basis of the clinical response.

Contra-Indications

Hypersensitivity to doxofulline and other methylxanthine derivatives. Methylxanthines are not recommended for therapy of asthma exacerbations.

Side Effects

Doxofylline has a prolonged bronchodilator effects,and unlike theophylline it has least adenosine interactions i.e., no CNS and CVS side effects. There is no sleep disturbances and no effects on gastric secretions with doxofylline. It is highly safe in smokers.