FLUOXETINE HYDROCHLORIDE
It is potent antidepressant with non-sedating properties. The anti-depressant action of fluoxetine is presumed to be linked to its inhibition of C.N.S. neuronal uptake of serotonin. Fluoxetine has negligible binding to muscarinic, histaminergic and alpha1-adrenergic receptors in comparision to ticyclic agents.All types of depression, especially where no sedation is required.
Initially 20 mg once a day in the morning followed by range of 20-80 mg per day, after several weeks if there is no therapeutic response.
Hypersensitivity. Severe renal failure, nursing mothers.
At least 14 days gap between discontinuation of MAO inhibitor & initiation of Fluoxetine. Pregnancy, lactation, possibility of suicide attempt, mania, hypomania or convulsions. Epileps, renal, hepatic or cardiac disease. Weight loss, driving, operating machinery. Paediatrics: Not recommended. Pregnancy: Safety not established. Lactation: The drug passes into breast milk and may affect the infant. Elderly: Reduced dose necessary.
Anxiety, nervousness, insomnia, drowsiness, fatigue or lethargy; tremor, sweating. G.I. complaints like anorexia, nausea, diarrhoea, light headedness
Tryptophan may produce agitation, restlessness and gastric distress. Increased sedative effects on the CNS. Fluoxetinereduces the breakdown of tricyclic antidpressants, change in serum lithium level.
