Fluvoxamine
It is a selective serotonin (5-HT) receptor inhibitor (SSRI). It is chemically unrelated to other SSRIs and clomipramine.Treatment of obsessions and compulsions in patients with obsessive and Compulsive disorder.
Adults: The recommended starting dose of fluvoxamine in adult patients is 50mg/day, administered as a single dose at bedtime. The effective dose range is 100 to 300mg/day. The dosage may be increased in 50mg increments every 4 to 7 days, until maximum therapeutic benefit is achieved or a maximum dosage of 300mg/day is reached. It is advisable that if daily dose is more than 100mg, it should be given in two divided doses; if the two doses are not equal, the larger doses should be given at bedtime
Coadministration of terfenadine, astemizole, or cisapride with Fluvoxamine is contraindicated. Patients with history of hypersensitivity to fluvoxamine maleate.
Activation of mania/hypomania. Seizures. Suicidal tendancy.
Headache , asthenia, flu like syndrome, and chills. Nausea, vomiting, flatulence, diarrhea, constipation, dyspepsia, agitation, decreased libido,anorexia, tooth disorder, dysphagia. Somnolence, dizziness, insomnia, dry mouth, nervousness, tremor, anxiety, vasodilatation, hypertonia, depression, CNS stimulation, Upper respiratory infection, Dyspnoea, amblopia. Abnormal ejaculation, yawn. Sweating. Taste preversion, impotence, anorgasmia, urinary frequency, urinary retention.
Drugs that are metabolized by and/or inhibit cytochrome P450 isoenzymes: A clinically significant fluvoxamine interaction is possible with drugs having a narrow therapeutic ration such as terfenadine, astemizole, cisapride, warfarin, theophylline, certain benzodiazepines and phenytoin.
