GLIPIZIDE

It is one of the second generation sulfonyl ureas, having a similar pharmacological profile, as that of Glibenclamide or gliclazide.

Indications

Non-insulin dependent diabetes mellitus.

Dosage

2.5-5 mg daily 1/2 hr before meals. Gradually increase by 2.5-5 mg at weekly intervals to max 20mg daily.

Contra-Indications

Juvenile Diabetes mellitus. Pregnancy, stress. Renal or hepatic dysfunction. Impaired adrenocortical function ketoacidosis. Diabetic pre-coma & coma.

Special Precautions

hypoglycaemia. It should be taken before or along with meals. Underweight, severe hepatic or renal disease. Paediatrics: Safety and efficacy not established. Pregnancy: Should not be used. Lactation: Use with caution. Elderly: Reduced dose may be necessary.

Side Effects

Nausea, urticaria, thrombocytopenia, vomiting, diarrhoea, drowsiness, headache, pruritus.

Drug Interactions

Hypoglycaeia enhanced by alcohol, sulphonamides, tri-methoprim. salicylate, & NSAIDs.Thiazide diuretics & b blockers antagonise hypoglycaemic action. Food delays absorption.