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Hydroxypropylmethyl cellulose (HPMC) is a derivative of cellulose, a natural polymer found in plants. It is commonly used in pharmaceuticals, cosmetics, and food products due to its properties as a thickener, stabilizer, and emulsifier. In medicine, HPMC is valued for its role in various formulations, particularly in eye drops and ophthalmic preparations.


-HPMC is primarily used to relieve dryness and irritation in the eyes, often in the form of lubricating eye drops. It helps to maintain moisture on the eye's surface, providing temporary relief from discomfort associated with dry eye syndrome. -Ophthalmic surgical aid in anterior segment surgical procedures including cataract extraction & IOL implantation during keratoplasty and filtering operations for glaucoma.


The dosage of HPMC eye drops typically involves applying 1 to 2 drops into the affected eye(s) as needed. Specific dosage instructions may vary depending on the product formulation and severity of symptoms. It is advisable to follow the prescribing physician's guidance or the product label.


Individuals with known hypersensitivity or allergy to hydroxypropylmethyl cellulose or any of its components should avoid using products containing HPMC.

Special Precautions

-Contact Lenses: HPMC eye drops may contain preservatives that can discolor soft contact lenses. It is advisable to remove lenses before application and wait at least 15 minutes before reinserting them. -Pregnancy and Nursing: While HPMC is generally considered safe, pregnant or nursing women should consult a healthcare professional before use.

Side Effects

-Common side effects may include temporary mild eye irritation or discomfort. Severe allergic reactions are rare but possible. Discontinue use and seek medical attention if you experience unexpected symptoms. -Rise in intraocular pressure post operatively, iritis, hypopyon, corneal oedema, corneal decompensation.

Drug Interactions

There are no known significant drug interactions associated with HPMC when used as eye drops. However, it is prudent to inform your healthcare provider about all medications you are taking, including over-the-counter products.

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