ITOPRIDE HYDROCHLORIDE
Itopride inhibits the dopamine D2 receptor at the parasympathetic nerve ends and thereby increases the release of acetycholine and decreases the metabolism of acetylcholine by inhibiting the enzyme acetylcholinesterase (AChE). By maintaining higher acetylcholine levels, itopride increases the esophageal and gastrointestinal peristalsis, increases the lower esophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying and improves gastro-duodenal coordination. Because of its dopamine D2 receptor antagonistic action, it also exerts anti-emetic actions.Treatment of gastrointestinal symptoms caused by reduced gastrointestinal motility such as feeling of gastric fullness, epigastric pain, anorexia, heartburn, regurgitation, bloating, nausea and vomiting.
Adult dosage is 150mg orally in 3 divided doses before meals.
Should be used with caution as it enhances the action of acetylcholine.
Diarrhoea, constipation, headache, abdominal pian, irritated feeling and dizziness.
Cisapride, atropine.
