Ketoprofen

All have similar pharmacodynamic properties but vary considerably in potency & to some extent in duration of action.

Indications

Analgesic, antipyretic, dysmenorrhoea, rheumatoid arthritis, osteoarthritis, musculo-skeletal disorders, soft tissue injuries, tooth extraction, post-partum and post operatively, acute gout

Dosage

Ketoprofen: 50 mg twice or thrice daily.

Contra-Indications

Pregnancy, active peptic ulcer, G.I. bleeding, lactation

Special Precautions

Asthma, bleeding disorders, cardiovascular disease&those receiving coumarin anticoagulants.Aspirin/anti-inflammatory induced allergy.

Side Effects

G.I. intolerance, rash, rarely jaundice, thrombocytopenia oedema

Drug Interactions

Aspirin displaces Ibuprofen from serum binding sites,reduces serum levels of Ketoprofen enhances effects of oral anticoagulants, phenytoin, methotrexate, sulphonamides, sulphonylurea hypoglycaemics & Probenecid increases their concentration