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Lenalidomide- Drug Interactions, Dosage, Side Effects, indications, Uses and Precautions

Look for Drugs and Conditions

Lenalidomide

Lenalidomide

Antineoplastic,immunomodulatory, and antiangiogenic properties. Inhibits the secretion of proinflammatory cytokines and increases the secretion of anti-inflammatory cytokines.

Indications

A thalidomide analogue, immunomodulatory agent with antiangiogenic & antineoplastic property to treat hematologic and solid cancers.


Dosage

Adult :For anemia : 10mg with water daily. For Multiple Myeloma : 25mg/day of Lenalidomide with water orally as a single 25mg capsules on days 1 through 21 of repeated 28 day cycles. Renal dose adjustments : Moderate renal function impairment. Multiple Myeloma : 10mg every 24 hours. Myelodysplastic Syndromes : 5mg every 24 hours. Severe renal function impairment:Multiple Myeloma : 15mg every 48 hours. Myelodysplastic Syndromes : 5mg every 48 hours.


Contra-Indications

Pregnancy, hypersensitivity.


Special Precautions

Breast-feed avoided allergic & kidney disease.


Side Effects

Diarrhea, loss of appetite, weight loss, decreased sense of touch & taste, blurred vision, depression, swelling of the arms, hands, feet, ankles, or lower legs, fast or pounding heartbeat, muscle cramps, thrombosis, pulmonary embolus, hepatotoxicity, myelo-suppression.


Drug Interactions

Digoxin


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