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Metoclopramide is a medication primarily used to treat gastrointestinal disorders such as nausea, vomiting, and gastroparesis. It works by increasing muscle contractions in the upper digestive tract, which helps to move food and fluid through the stomach and intestines more quickly.


Metoclopramide is indicated for the treatment of: -Nausea and vomiting caused by chemotherapy or surgery -Gastroparesis (delayed emptying of the stomach) -Gastroesophageal reflux disease (GERD) -Heartburn


The dosage of metoclopramide varies depending on the condition being treated and the individual's response to the medication. It is typically taken orally, usually 30 minutes before meals and at bedtime. The recommended adult dose for nausea and vomiting is 10-20 mg, up to 4 times daily. For other conditions, the dosage may be different.


-Hypersensitivity to metoclopramide or any of its components -Gastrointestinal obstruction, perforation, or hemorrhage -Pheochromocytoma -History of tardive dyskinesia or neuroleptic malignant syndrome

Special Precautions

-Use with caution in patients with a history of depression, Parkinson's disease, or other movement disorders -Avoid use in patients with a history of seizures -Avoid prolonged use, as it may increase the risk of developing tardive dyskinesia

Side Effects

Common side effects of metoclopramide may include: -Drowsiness -Restlessness -Fatigue -Diarrhea -Headache -Breast tenderness or enlargement (gynecomastia) -Menstrual irregularities Less common but more serious side effects may include: -Tardive dyskinesia (involuntary muscle movements, especially of the face) -Neuroleptic malignant syndrome (a potentially life-threatening reaction characterized by fever, muscle rigidity, and altered mental status) -Extrapyramidal symptoms (muscle stiffness, tremors, etc.)

Drug Interactions

Metoclopramide may interact with other medications, including: -Anticholinergic drugs Dopamine antagonists -Monoamine oxidase inhibitors (MAOIs) -Antipsychotic medications -Serotonergic drugs

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