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Metoprolol with Amlodipine

Metoprolol with Amlodipine

-Metoprolol with Amlodipine is a combination medication that includes Metoprolol, a beta-blocker, and Amlodipine, a calcium channel blocker. This combination is used to manage hypertension (high blood pressure) and certain cardiovascular conditions by reducing the workload of the heart and relaxing blood vessels. -Metoprolol Succinate and Amlodipine is a combination which lowers blood pressure effectively. Metoprolol is a beta blocker that works specifically on the heart to slow down the heart rate while Amlodipine is a calcium channel blocker which helps in relaxing blood vessels. Both the salt together makes the heart more efficient at pumping blood throughout the body.


-Hypertension: Used to lower blood pressure in patients with essential hypertension. -Angina Pectoris: Effective in the management of stable angina pectoris. -Cardiac Conditions: May be prescribed for certain cardiovascular conditions in conjunction with other medications.


Dosage is determined based on the specific needs of the patient, the severity of hypertension, and other cardiovascular conditions. The combination is usually administered orally.


-Hypersensitivity: Avoid in patients with known hypersensitivity to metoprolol, amlodipine, or related components. -Severe Bradycardia: Contraindicated in patients with severe bradycardia (slow heart rate).

Special Precautions

-Heart Failure: Use with caution in patients with heart failure; monitor heart function closely. -Hepatic Impairment: Adjustments in dosage may be necessary in patients with liver dysfunction.

Side Effects

-Common side effects may include dizziness, fatigue, and peripheral edema. Serious side effects are rare but may include bradycardia, hypotension, and exacerbation of heart failure. -Nausea,Dizziness, Fatigue, Sleepiness, Ankle swelling,Vomiting,Constipation, Edema (swelling), Palpitations, Abdominal pain, Headache, Visual disturbance, Orthostatic hypotension (sudden lowering of blood pressure on standing), Breathlessness, Muscle cramp,Slow heart rate,Flushing (sense of warmth in the face, ears, neck and trunk).

Drug Interactions

-CYP3A4 Inhibitors: Caution is advised when combining with drugs that inhibit CYP3A4, as this may increase amlodipine levels. -Beta-Blockers: Potential additive effects on heart rate and blood pressure.

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