Natural Micronised Progesterone

A micronised porgesterone, identical to that secreted by the human ovary, with improved bioavailability.

Indications

Sterility due to luteal deficiency; treatment of puerperal depression; maintenance of pregnancy in cases of threatened or habitual abortion; premenstrual syndrome; benign mastopathies; DUB; in menopause to reduce the risk of endometrial hyperplasia and carcinoma in post-menopausal women receiving conjugated oestrogens.

Dosage

Maintenance of pregnancy in cases of habitual or threatened abortion : 200 to 400 mg per day in divided doses. For premenstrual syndrome : 200-400mg 1-2 times daily from the 12th to 14th day of the cycle until onset of menstruation. For puerperal depression : 400 mg twice daily in divided doses. Supplementation of the luteal phase in case of sterility due to luteal deficiency : 400 to 600mg per day up to the 12th week of pregnancy.

Contra-Indications

Hypersensitivity, undiagnosed vaginal bleeding, abnormal liver function, hormone dependent carcinoma, thrombophlebitis, thromboembolic disorder, cerebral.

Special Precautions

Epilepsy, migraine, asthma, cardiac or renal dysfunction. Avoid driving or operating hazardous machinary. Monitor diabetic patients receiving oestrogen-progesterone combination therapy. Pregnancy : If given in the second and third trimester of pregnancy it can lead to a severe cholestatis or hepatitis.

Side Effects

Drowsiness, giddiness, weight gain or loss and skin reactions such as acne. Soreness, diarrhoea and flatulence may occur after rectal administration, menstrual irregularities or intermenstrual bleeding.