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Nortriptyline is a tricyclic antidepressant (TCA) primarily used to treat depression. Gabapentin is an anticonvulsant medication also used for neuropathic pain and as an adjunctive therapy for seizures. The combination of nortriptyline and gabapentin may be prescribed for conditions such as neuropathic pain or treatment-resistant depression.


-Neuropathic pain -Treatment-resistant depression -Fibromyalgia (off-label use)


Dosage varies depending on the individual's condition, medical history, and response to treatment. It's crucial to follow the prescribing doctor's instructions carefully.


-Hypersensitivity to nortriptyline, gabapentin, or any components of the medications -Recent myocardial infarction -Concomitant use of MAO inhibitors

Special Precautions

-Caution in patients with a history of cardiovascular disease, seizures, urinary retention, or glaucoma. -Monitor for signs of worsening depression or suicidal ideation, especially in the initial weeks of treatment. -Avoid abrupt discontinuation; taper dose gradually to minimize withdrawal symptoms. -Use with caution in elderly patients due to increased risk of falls and cognitive impairment.

Side Effects

-Sedation -Dizziness -Dry mouth -Constipation -Weight gain -Blurred vision -Urinary retention -Orthostatic hypotension -Cardiac arrhythmias (less common with gabapentin)

Drug Interactions

-MAO inhibitors: Increased risk of hypertensive crisis. -Anticholinergic drugs: Enhanced anticholinergic effects. -CNS depressants: Enhanced sedative effects. -Cimetidine: Increased nortriptyline levels. -Warfarin: Potential for increased anticoagulant effects.

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