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Pioglitazone with Glimepiride

Pioglitazone with Glimepiride

Pioglitazone with Glimepiride is a combination medication used in the management of type 2 diabetes mellitus. It combines two different classes of anti-diabetic drugs: pioglitazone, a thiazolidinedione, and glimepiride, a sulfonylurea. These medications work together to improve blood sugar control.


Pioglitazone with Glimepiride is indicated for the treatment of type 2 diabetes mellitus in adults when diet and exercise alone do not provide adequate glycemic control.


The dosage of Pioglitazone with Glimepiride should be individualized based on the patient's response and tolerance. It is typically taken once daily with or without food. The specific dosage will depend on the patient's current regimen and overall health.


Pioglitazone with Glimepiride is contraindicated in patients with a history of hypersensitivity to any component of the medication, as well as in patients with severe heart failure, active liver disease, or diabetic ketoacidosis.

Special Precautions

-Caution is advised in patients with a history of cardiovascular disease. -Liver function should be monitored regularly during treatment. -Hypoglycemia (low blood sugar) may occur, especially in elderly or malnourished patients.

Side Effects

Common side effects may include weight gain, edema (fluid retention), headache, and hypoglycemia. Serious side effects may include liver problems, heart failure, and an increased risk of fractures.

Drug Interactions

Pioglitazone with Glimepiride may interact with certain medications, including: -Insulin or other oral antidiabetic drugs. -Rifampin and other inducers of CYP2C8 enzyme. -Gemfibrozil and other inhibitors of CYP2C8 enzyme It's crucial to inform healthcare providers about all medications being taken to avoid potential interactions.

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