Pregabalin

It is an analog of the neurotransmitter GABA. It binds potently to the alpha2-delta subunit resulting in modulation of Ca channels and reduction in the release of several neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine and substance P.

Indications

Treatment of neuropathic pain in adult.

Dosage

75-150mg bid. May increase up to 600mg/day in patients with ongoing pain and can tolerate 300mg/day.

Contra-Indications

Hypersensitivity.

Side Effects

Dizziness, drowsiness, visual disturbance (including blurred vision, diplopia), ataxia, dysarthria, tremor, lethargy, memory impairment, euphoria, weight gain, constipation, dry mouth, confusion, agitation.