Raloxifene
It is a Selective Estrogen Receptor Modulator (SERM), a new form of antiresorptive therapy that reduces the risks of osteroporosis and also improves the cardiovascular profile in postmenopausal women.Postmenopausal osteoporosis.
60mg per day.
Pregnancy and lactation, hypersensitivity, hepatic insufficiency.
It should be used with caution in patients taking highly protein bound drugs such as diazepam, diazoxide and lidocaine. In patients taking concomitant warfarin or other coumarin derivatives, prothrombin times should be closely monitored when starting or stopping raloxifene treatment. Concomitant use of raloxifene with systemic estrogens or cholestyramine is not recommended.
Hot flushes, leg cramps, sweating, sleep disorders, peripheral oedema, vaginal bleeding, endometrail carcinoma and thromboembolic events.
Cholestyramine reduces the absorption and enterohepatic recycling of raloxifene. Ampicillin reduces peak concentration and absorption of raloxifene. Coadministration with warfarin reduces the prothrombin response and time.
