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Sildenafil Citrate

Sildenafil Citrate

It is a selective inhibitor of cyclic guanosine monophosphate specific phosphodiesterase type 5 (PDE5). When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum.

Indications

For the treatment of erectile dysfunction.


Dosage

The recommended dose is 50mg per day as needed, approx. 1 hour before sexual activity. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100mg or decreased to 25mg.


Contra-Indications

In patients, on nitrate therapy and with a known hypersensitivity to any component of the tablet.


Special Precautions

In patients with bleeding disorders, active peptic ulceration and anatomial deformation of the penis.


Side Effects

Headache, flushing, dyspepsia, nasal congestion, abnormal vision, diarrhoea, dizziness and rashes may occur.


Drug Interactions

Interaction with erythromycin, cimetidine, ketoconazole, itraconazole, rifampicin is noted.


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